Texas Woman’s University
Dr. Michael Bergel is currently an associate professor at Texas Woman’s University (TWU), the largest university primarily for women in the United States. At TWU his lab demonstrated that the high mobility group nucleosomal binding proteins HMGN2 and HMGN1 are required for an efficient nucleotide excision repair (Subramanian et al., FEBS J. 2009) and that after UV irradiation of cells there is a wave of decreasing core histone acetylation and other global chromatin changes followed by a return to the steady state levels after 24-48 hours. Dr. Bergel’s lab currently analyzes this chromatin response to UV irradiation and its biological significance. His fascination with chromatin compaction and decompaction also led to the discovery of a novel H1.3-HDAC3 complex that includes 6 additional proteins and is involved in mitotic regulation by compacting the mitotic chromosomes and by regulating microtubule dynamics (Patil et al., 2015, Dec 9. pii: jbc.M115.643874.). Dr. Bergel’s lab has recently submitted a provisional patent application: U.S. Provisional Patent Application No. 62/567,089 entitled “Use of Histone Acetyltransferase Inhibitor Amidoximes as Anti-Proliferative Agents” ,filed October 2, 2017. During his postdoctoral training at the NIH, NCI with Dr. M. Bustin, Dr. Bergel specialized in the field of chromatin. Specifically, he studied the HMGN1/2 proteins and their acetylation by the histone acetyltransferases p300 and PCAF (Bergel et al., J. Biol. Chem., (2000), 275(15):1151). He also demonstrated that HMGNs are involved in regulation of core histone posttranslational modifications (J-H Lim et al., EMBO J.,(2005), 24(17):3038-48). Dr. Bergel later joined the lab of Dr. D.S. Schrump and Dr. S.A. Rosenberg, Surgery Branch, NCI, as a Research Fellow, where he worked on HDAC inhibitors and identified novel non-histone-HDAC complexes. Dr. Bergel obtained his Master’s and Ph.D. from The Hebrew University of Jerusalem in the field of cancer biology, mentored by Dr. Jacob Ochman.
chromatin compaction and decompaction