Integrative Biology

Biography

Xiang-Qun (Sean) Xie received his Pharmacy B. S. degree in 1982 from the Second Military Medical University in Shanghai, China; Ph.D. in Medicinal Chemistry from the School of Pharmacy, University of Connecticut, 1993; and followed by a Biophysics Post-doctoral training at MIT Francis Bitter National Magnet Laboratory. In addition, he obtained Executive MBA degree in 2003. Currently, Xie is a tenured Professor of Pharmaceutical Sciences and Drug Discovery Institute. He is the Principal Investigator of an integrated research laboratory, consisting of CompuGroup, BioGroup and ChemGroup (www.CBLigand.org/XieLab) and also a Founding Director of Computational Chemical Genomics Screening (CCGS) Center. He was co-PI of the NIH Pittsburgh Molecular Library Screening Center. He also holds joint faculty positions at the Departments of Computational Biology and Structural Biology, and Pitt Cancer Institute MT/DD Program. Before he joined Pitt, he was an Associate Professor and a Founding Director of Pharmacoinformatics Research Center in the College of Pharmacy at University of Houston Texas.

Research Interest

Xie’s research interests are: 1) GPCR CB2 membrane protein structure/function studies. 2) Methods and algorithms development for knowledgebase-target identifications and structure-based drug design for multiple myeloma, osteoporosis and hematopoietic stem cell expansion by using the integrated computational chemical genomics, in-silico design and 3D database virtual screening, bioassay validation and medicinal chemistry approaches.