6^th International Conference on Integrative Biology May 21-23, 2018 Barcelona, Spain

Xiang-Qun (Sean) Xie, MD, PhD, EMBA is an Associate Dean and Professor of the School of Pharmacy, and a PI of an integrated Medicinal Chemistry Biology Laboratory of Compu Group, Bio Group and Chem Group at the University of Pittsburgh. He serves as a FDA Science Board Member. He is a Director/PI of NIDA-funded National Center of Excellence for CDAR (www.CDARCenter.org). He serves as an Editorial Advisory Board member for AAPS Journal. He was a Charter Member of NIH BPNS Study Section, and an ad hoc expert reviewer for UK MRC foundation; the Wellcome Trust Fund; the Netherland Organization for Scientific Research Council; the Austrian Science Fund (FWF); and the Chinese Natural Science Foundation. Xie’s team is known for its pioneering research on development of “Big Data to Knowledge” GPU-accelerated diseases-specific chemo genomics knowledge bases and machine-/deep-learning algorithm Target Hunter platform for target identification and system pharmacology translational research. His recent published work (www.CBLigand.org/CCGS) includes Alzheimer’s disease knowledgebase (2014 ACS JCIM cover page story); innovative GPU-accelerated cloud computing Target Hunter program for drug target identification (2013 AAPS special theme issue); the first discovered/patented INK4C-targeting small-molecule modulators for hematopoietic stem cell expansion (Nature Comm 2015; Sci Reports, 2015); the first discovered/patented p62ZZ chemical inhibitors for multiple myeloma (Nature Leukemia 2016, Nature Comm 2017); the first on Nature Scientific Report (2016) about cardiovascular disease-specific chemo genomics knowledgebase-guided target identification and drug synergy mechanism study of a combination of herbal medications "Sini Decoction" (四逆汤); and also reported/patented novel ligands specific to cannabinoid CB2 receptor for osteoporosis and cancers (JMC, PNAS). He was also a recipient of 2014 AAPS Award for Outstanding Research Achievements. Sean Xie received his MD in Pharmacy 1982 from the 2nd Military Medical University, China; his PhD in Medicinal Chemistry 1993 from the School of Pharmacy, University of Connecticut, USA; and Executive MBA degree 2003.

integrated Medicinal Chemistry Biology, recent published work includes Alzheimer’s disease knowledge base, and chemo genomics.

Luisa María Arvide Cambra, Spanish is now Professor with Chair at the University of Almería (Spain) and she was Lecturer at the University of Granada. Thirty six years of the teaching and researching experience. She is Director of Research Group HUM113-Estudios Filológicos from Program of Research of Andalusian Government, where she has managed and directed several academic and scientific contracts and research projects, as well as Member of European Scientific Institute (ESI) management team, and Athens Institute for Education & Research (ATINER), etc.She is author of a many works on several aspects of the Arabic science and literature in the Middle Ages, as well as Arabic language and linguistics. She has also participated in different prestigious international scientific Conferences. She has visited a many universities and academic institutions of Europe, United States and Arab countries in order to teach and research. Among her works, we have the study and the translation to Spanish of some treatises of Kitab al-tasrif´s Al-Zahrawi, Ibn Qutayba´s texts, Maqamas of Al-Hariri, The Sicilian Questions of Ibn Sab´in, etcetera. Honors and awards -Included and enlisted in Marquis Who´s Who in the World, USA. -Included and enlisted in 2000 Outstanding Intellectuals of the 21st Century 2011. International Biographical Centre. Cambridge, UK. -Included and enlisted in Great Minds of 21st Century, American Biographical Institute. Raleigh, North Carolina, USA. -Top 100 Professionals 2011. International Biographical Centre. Cambridge, UK -Woman of the Year 2011 by the American Biographical Institute. Raleigh, North Carolina, USA. -Deputy Director General for Europe of International Biographical Centre. Cambridge, UK. -Collaborator in QS World Intelligence Unit. London, UK. -International Jury Member of Ana María Agüero Melnyczuk Awards. Buenos Aires, Argentina. June 2013. -Reviewer and Member of the Editorial Board in several renowned international journals as well as member of the scientific & academic committee at prestigious international conferences.

Filología

Reiko Kuroda is the Emeritus Professor of the University of Tokyo. She was graduated in 1970 from Ochanomizu University Faculty of Science Department of Chemistry. She has obtained her PhD in Chemistry from The University of Tokyo in the year of 1975 and carried out Postdoctoral studies at King’s College London. She was the Honorary Lecturer in 1982 Ibid. she worked for Cancer Institute of UK in 1985. She also holds the experience of teaching in King University College London Department of Biophysics, UK Honorary Lecturer, Faculty of Education, University of Tokyo Faculty of Science, Graduate School of Science, Tokyo University Associate Professor of Biochemistry, Professor, Department of Chemistry, University of Tokyo, in 1992 Faculty of Science, University of Tokyo Graduate School of Biochemistry, Graduate School of Culture, University of Tokyo in 1996, University of Tokyo Emeritus Professor. She is the Member of the Research Promotion Organization. She also got Tokyo University of Science Membership of the Royal Academy of Sciences of Sweden. Her research focuses on chirality both in the field of chemistry and biology: Chirality recognition, transfer and amplification in the solid state, development of chiroptical spectrophotometers to follow aggregation processes of e.g., β-amyloids and the molecular basis of snail coiling. She has 320 papers published to her credit. The recent awards which she got are • 2015 National College of Japanese Studies Heisei 26th Academia Prize (Cultural Section) • 2014 Heisei 26 year Foundation of Gender Equality Society Merit Award of Prime Minister of Merit Achievement • 2014 25th Mukai Prize "Development of Solid Chiral Chemistry and Development of a New Chiral Spectrometer" • 2013 L'Oreal - UNESCO Women's Science Award (Physics Science Section) • 2009 Royal Swedish Academy of Sciences Foreign Residents (Chemistry Division) • 2009 Minister of Science and Technology in recognition of (research department) • 2009 Minister of Science and Technology in recognition of (research department) Representative Director General of the University of Tokyo, representatives of the Management Council, representatives of the Science and Technology Interpreter Training Program etc. At government agencies, the Council for Science and Technology Policy Council (2001-2007), the Ministry of Education, University Education, the Education Minister, the Ministry of Internal Affairs and Communications, Members of the Japan National Committee for UNESCO, Cabinet Office Gender Equality Promotion Collaboration Council etc. HFSP Scientific Committee Member, Vice Chairman of ICSU (International Scientific Council) (2008-2011) etc. Outside the country Currently Tohoku University Management Association Committee Research graduate school management council committee, Sony Educational Foundation board director, Furukaa scholarship association, talent development education foundation board, C & C foundation councilor etc

Chemistry and biology, especially science of chirality (left-right asymmetry)

Hans Lehrach studied Chemistry at the University of Vienna and obtained his Ph.D. at the Max Planck Institute for Experimental Medicine and the Max Planck Institute for Biophysical Chemistry in 1974. As postdoctoral fellow at Harvard University, Cambridge (1974-1978) his research focused on RNA analysis and he carried out one of the first cDNA cloning experiments. As group leader at the EMBL, Heidelberg (1978-1987), he was among the first who initiated positional cloning experiments in mouse (Brachyury) and man (Huntington’s disease, Cystic Fibrosis etc), he also contributed to the development of widely used research tools (e.g. the EMBL vector system together with Noreen Murray) and was one of the first who initiated the human genome project. Following this, he moved to the Imperial Cancer Research Fund, London (1987-1994) as head of Genome Analysis Department, focusing on the development of new structural and functional genome analysis technologies (e.g. development of the first array robotics in 1987). In 1994, he returned to Germany and since then he has been Director and Scientific Member at the Max Planck Institute for Molecular Genetics, with a focus on genetics, genomics and systems biology. His scientific achievements are numerous, among those are the early contribution to the cloning of collagen cDNA, early positional cloning work (Chorea Huntington gene etc.), key work on technologies such as protein microarrays, protein interactome analysis, yeast artificial chromosomes and RNAseq, as well as the involvement in several genome sequencing projects, such as the human, rat, and Schizosaccharomyces Pombe. During the last decade, a major focus of his work has been the development of a new, truly personalised medicine on the basis of ‘virtual patient’ models, based on a deep –omics analysis of the patient. He has received several awards such as the Ján Jessenius SAS Medal of Honour for outstanding achievements in medical sciences of the Slovak Academy of Sciences (2003) and the Karl Heinz Beckurts Award for achievements in genome research (2004). Hans Lehrach has co-founded several biotechnology companies such as Sequana Therapeutics, GPC Biotech, Scienion, Prot@gen, PSF Biotech, Atlas Biolabs, Alacris Theranostics, as well as the Dahlem Centre for Genome Research and Medical Systems Biology gGmbH (DCGMS).

protein microarrays, protein interactome analysis, yeast artificial chromosomes and RNAseq, as well as the involvement in several genome sequencing projects, such as the human, rat, and Schizosaccharomyces Pombe

Deepak Bastia studied M.S., IARI, from New Delhi, India in 1965. He has completed Ph.D. from University of Chicago, Chicago, IL in 1971. He worked as Postdoctoral Fellow in Princeton University, Princeton, NJ (1971-72), Postdoctoral Fellow in University of Colorado, Boulder, CO(1972-74), Postdoctoral Fellow in Yale University, New Haven, CT (1974-77). He was Assistant Professor in UAB, Birmingham, AL during the period of 1977-1979. He was the Associate Professor at Duke University Medical Center, Durham, NC during 1979-1985. He worked as a Professor in Duke University Medical Center, Durham, NC in 1985-2001. Later he was appointed as Gaylord and Dorothy Donnelley Chair in Biomedical Sciences

Biochemistry and Molecular Biology

Mehmet Karaca was the first rank graduate amongst the all departments in Faculty of Agriculture in Trakya University in 1991. He ranked the first in a national student competition exam of Ministry of Education of Turkey and was awarded to be sent to abroad to pursue MS and PhD. studies in 1993. He completed his MS degree in Genetics in 1996 and Ph.D. in Agronomy (major) and Molecular Biology (minor) from Mississippi State University, USA, in 2001. He became Associate Professor in 2006 and Professor in 2017 in Akdeniz University, Turkey. His main interest is molecular genetics and epigenetic research. He teaches several classes for undergraduate, MS and Ph.D. students, serves in editorial boards of several international journals and scientific advisory committees. He was principle investigator for several projects including international ones involving with medicinal plants, cotton and main horticultural crops. He has an h-index of 18 and an i10-index of 32 as date of 2017. He has been given the Science Encouragement Award of Akdeniz University and the Science Award of the Chamber of Agricultural Engineers of the chambers of Turkish Engineers and Architects.

molecular genetics and epigenetic research

Prof. H.P.Puttaraju obtained B.Sc. and M.Sc. degree in Zoology from University of Mysore and started his research career in Bangalore University with the DST project fellowship on Mosquito cytogenetics and obtained Ph.D degree. He Carried out research and teaching at Master‘s level for over 30 years. He is the Professor of Sericulture/life sciences and founder Coordinator & Chairman (BOS/BOE) for Biological Sciences and founder Coordinator for UGC-Innovative Programme ,School of Natural Science of Bangalore University, at present. He Received prestigious Commonwealth Academic staff fellowship to carryout research for one year (1998-1999) at Cardiff University of Wales, UK. He got Selected as visiting scientist, University of Bremen, Germany under DFG-INSA bilateral exchange programmes 2010. He Received funding for personal research and coordinated projects from UGC, DST, DBT,DST,ICMR, DAE-BRNS and from Bangalore University . Recipient of the coveted Karnataka state Sir C.V. Raman Young Scientist award for his outstanding contribution in Life sciences for the year 2004 given by the Chief Minister Govt. of Karnataka. He Recognized as one of the Investigators of UGC award for Centre for Potential for Excellence in Bangalore University with Rs. 5.75 Crore in 2011-12. He got Elected Fellow of the Royal Entomological Society, London (FRES) in 1999. He is the Member, Peer Review Committee, NAAC, India. Selected as Coordinator to conduct DST-INSPIRE Science Program of DST. Govt. of India at Bangalore University for the year 2011, 2012 and 2013. He is the Member Evaluation Award Committee- VGST, Govt. of Karnataka. During the past 15 years organized several conferences, Seminars, science camps, workshops, lecture series and Refresher course in Life sciences etc.,. He Delivered lectures/presented papers at many Universities in India and abroad(USA, UK, Canada, Australia, Japan, Germany, Egypt, South Africa, China, Singapore and other ). He Served/Serving as member/Chairman of BOS, BOE, BOA and several academic committees of Bangalore and other Universities in the state and outside. He Published over150 research papers, articles in national and international journals of high repute, 3 books and guided successfully 17Ph.Ds and 7 M. Phil research degrees. Subject expert to evaluate the projects and awards of various agencies including TWAS. He got Nominated as DBT representative in the IBSC of Seri biotechnology Laboratory, Bangalore. He was Awarded with UGC-BSR onetime grant under FRPS given to active researchers of India.

Sericulture and life sciences

Dr. Ling Tau Chuan has completed BSc(Hons)(Biotechnology) from UNIVERSITI PERTANIAN MALAYSIA and MSc(Environmental Engineering) from UNIVERSITI PUTRA MALAYSIA (UPM). He took his Ph.D from (Chemical Engineering), BIRMINGHAM UNIVERSITY, BIRMINGHAM, UK. He is the member of following societies: Malaysia Society of Molecular Biology and Biotechnology, Member, 2009, (National), Federation of European Biotechnology, Member, 2009, (International), American Chemical Society, Member, 2010, (International), CHARTERED ENGINEER OF ENGINEERING COUNCIL, UNITED KINGDOM (CENG), Charted Engineer, 2011, (International), The Institution of Chemical Engineer (IChemE), Member, 2013, (International), Current Biochemical Engineering Journal, Chief Editor, 2013, (International). He worked as Faculty in Ahli Jawatankuasa Promosi Program Fakulti Sains, from 01/10/2015 to 31/12/2017. And he was the Faculty of Science in Jawatan Kuasa Ijazah Tinggi (Fakulti), Institute of Biological Sciences, from 23/07/2013 to 01/05/2015. He was the Coordinator for Master of Biotechnology, Institute of Biological Sciences from 01/07/2012 to 30/06/2013.

Bioprocess Engineering (Bioproducts and Food Processing), Downstream Processing (Bioseparation, Product Recovery, Adsorbent and Porous Materials ).

Dr. Michael Bergel is currently an associate professor at Texas Woman’s University (TWU), the largest university primarily for women in the United States. At TWU his lab demonstrated that the high mobility group nucleosomal binding proteins HMGN2 and HMGN1 are required for an efficient nucleotide excision repair (Subramanian et al., FEBS J. 2009) and that after UV irradiation of cells there is a wave of decreasing core histone acetylation and other global chromatin changes followed by a return to the steady state levels after 24-48 hours. Dr. Bergel’s lab currently analyzes this chromatin response to UV irradiation and its biological significance. His fascination with chromatin compaction and decompaction also led to the discovery of a novel H1.3-HDAC3 complex that includes 6 additional proteins and is involved in mitotic regulation by compacting the mitotic chromosomes and by regulating microtubule dynamics (Patil et al., 2015, Dec 9. pii: jbc.M115.643874.). Dr. Bergel’s lab has recently submitted a provisional patent application: U.S. Provisional Patent Application No. 62/567,089 entitled “Use of Histone Acetyltransferase Inhibitor Amidoximes as Anti-Proliferative Agents” ,filed October 2, 2017. During his postdoctoral training at the NIH, NCI with Dr. M. Bustin, Dr. Bergel specialized in the field of chromatin. Specifically, he studied the HMGN1/2 proteins and their acetylation by the histone acetyltransferases p300 and PCAF (Bergel et al., J. Biol. Chem., (2000), 275(15):1151). He also demonstrated that HMGNs are involved in regulation of core histone posttranslational modifications (J-H Lim et al., EMBO J.,(2005), 24(17):3038-48). Dr. Bergel later joined the lab of Dr. D.S. Schrump and Dr. S.A. Rosenberg, Surgery Branch, NCI, as a Research Fellow, where he worked on HDAC inhibitors and identified novel non-histone-HDAC complexes. Dr. Bergel obtained his Master’s and Ph.D. from The Hebrew University of Jerusalem in the field of cancer biology, mentored by Dr. Jacob Ochman.

chromatin compaction and decompaction